Screening of biologically active monosaccharides: growth inhibitory effects of d-allose,d-talose,and l-idose against the nematode Caenorhabditis elegans |
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| Authors: | Hirofumi Sakoguchi Akihide Yoshihara Ken Izumori |
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| Institution: | 1. Faculty of Agriculture, Department of Applied Biological Science, Kagawa University, Miki, Japan;2. Rare Sugar Research Center, Kagawa University, Miki, Japan |
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| Abstract: | We compared the growth inhibitory effects of all aldohexose stereoisomers against the model animal Caenorhabditis elegans. Among the tested compounds, the rare sugars d-allose (d-All), d-talose (d-Tal), and l-idose (l-Ido) showed considerable growth inhibition under both monoxenic and axenic culture conditions. 6-Deoxy-d-All had no effect on growth, which suggests that C6-phosphorylation by hexokinase is essential for inhibition by d-All. |
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| Keywords: | growth inhibitory effect aldohexose Caenorhabditis elegans rare sugar |
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