Characterization of an RNA receptor motif that recognizes a GCGA tetraloop |
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| Authors: | Airi Furukawa Takaya Maejima Shigeyoshi Matsumura |
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| Institution: | Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan |
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| Abstract: | Tertiary interactions between a new RNA motif and RNA tetraloops were analyzed to determine whether this new motif shows preference for a GCGA tetraloop. In the structural context of a ligase ribozyme, this motif discriminated GCGA loop from 3 other tetraloops. The affinity between the GCGA loop and its receptor is strong enough to carry out the ribozyme activity. |
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| Keywords: | GNRA tetraloop RNA motif riboswitch ribozyme tertiary interaction |
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