Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice |
| |
| Authors: | Ryoji Yoshimura Kimiko Minami Junichiro Matsuda Naoki Sawada Shinji Miura |
| |
| Institution: | 1. Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan;2. Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan;3. Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan;4. Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA;5. Global COE Program, Tokyo Medical and Dental University, Tokyo, Japan;6. Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan |
| |
| Abstract: | Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1α knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1α knockout mice. These data suggest that skeletal muscle-PGC-1α is important for leucine-mediated mTOR activation and protein biosynthesis. |
| |
| Keywords: | leucine muscle specific PGC-1α knockout mouse 4EBP mTOR |
|
|
