Biological activities of unique isoflavones prepared from Apios americana Medik |
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| Authors: | Haruna Kaneta Mina Koda Shun Saito Masaya Imoto Manabu Kawada Yoko Yamazaki |
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| Affiliation: | 1. Department of Food and Nutrition, Japan Women’s University, Tokyo, Japan;2. Faculty of Science and Technology, Department of Biosciences and Informatics, Keio University, Yokohama, Japan;3. Microbial Chemistry Research Foundation Institute of Microbial Chemistry (BIKAKEN), Numazu, Japan |
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| Abstract: | Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1–4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities. |
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| Keywords: | Apios americana Medik isoflavone estrogen agonistic activity antioxidant activity α-glucosidase inhibitory activity |
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