The effects of Chamaecyparis obtusa essential oil on pain-related behavior and expression of pro-inflammatory cytokines in carrageenan-induced arthritis in rats |
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| Authors: | Hye Rim Suh Hyun Joo Chung Eui Ho Park Sun Wook Moon Su Jin Park Chan Woo Park |
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| Affiliation: | 1. Department of Physiology, College of Medicine and Neuroscience Research Institute, Korea University , Seoul, South Korea;2. Department of Forest Welfare, Korea Forest Research Institute , Seoul, South Korea |
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| Abstract: | Chamaecyparis obtusa essential oil (COE) has been widely used to treat allergic diseases and was suggested to exert anti-inflammatory, antioxidant, and antimicrobial effects. This study evaluated the effects of COE on pain-related behavior and pro-inflammatory cytokines in rats with carrageenan (CGN)-induced arthritis. Reduced dynamic weight load on inflamed joint in voluntarily walking rats was used as the behavior test for arthritic pain; 10% COE-treated group was significantly attenuated pain (6–8 h post-CGN injection) compared to VEH (mineral oil)-treated group. In addition, the protein levels of interleukin (IL)-1β, tumor necrosis factor-α, IL-6 (6–8 h), and cyclooxygenase (COX)-2 (8 h) within the synovial membrane, as well as IL-1β, COX-2 (6–8 h), and IL-6 (5–7 h) within the meniscus, of 10% COE-treated group were significantly reduced. The current results implicate that COE has anti-inflammatory and anti-nociceptive effects on arthritis in rats. |
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| Keywords: | Chamaecyparis obtusa essential oil carrageenan-induced arthritis pro-inflammatory cytokines dynamic weight load |
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