A single aldehyde group can serve as a structural element for recognition by transmembrane protein CD36 |
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| Authors: | Satoshi Tsuzuki Takahiko Amitsuka Tatsuya Okahashi Yuki Kozai Shigenobu Matsumura Kazuo Inoue |
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| Institution: | 1. Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan;2. R&3. D Center, T. Hasegawa Co., Ltd., Kawasaki, Japan |
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| Abstract: | Transmembrane protein CD36 is considered to bind its distinct ligands such as long-chain fatty acids primarily by recognizing their terminal carboxyl moiety. In this study, we provide evidence that long-chain fatty aldehydes, such as oleic aldehyde, can be recognized by CD36. We suggest that a single aldehyde group may also serve as one of the structural elements recognizable by CD36. |
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| Keywords: | aldehyde functional group CD36 ligands fatty acid-related molecules oleic aldehyde receptor-binding moiety |
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