Tumor cell-derived secretory factor downregulates Semaphorin-3a in osteoblasts by activating mammalian target of rapamycin pathway |
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| Authors: | Daisuke Yamada Kohichi Kawahara Masanobu Ozaki |
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| Affiliation: | 1. Faculty of Pharmacy, Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan;2. Faculty of Pharmacy, Department of Toxicology, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan |
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| Abstract: | We found that conditioned medium derived from Lewis Lung Carcinoma cells down-regulated Semaphorin3a (Sema3a) mRNA expression and increased the activity of mammalian target of rapamycin complex 1 (mTORC1) in osteoblast-like MC3T3-E1 cells. Furthermore, mTORC1 inhibition with rapamycin counteracted the effect of conditioned media on Sema3a mRNA expression. These results suggest that tumor cells decrease Sema3a mRNA expression in osteoblast in an mTORC1-dependent manner. |
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| Keywords: | osteoblast Semaphorin-3a mTORC1 |
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