Total synthesis of ceramide trihexoside accumulating with Fabry's disease. |
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| Authors: | D Shapiro A J Acher |
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| Institution: | Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot Israel |
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| Abstract: | We report the synthesis of natural ceramide trihexoside, viz. gal (alpha-1 leads to 4) gal (beta-1 leads to 4) gluc (beta-1 leads to 1) ceramide (XIII). It involves the Koenigs-Knorr reaction of the bromide II with the aglucon XIX, and of the chloride VII with the D-enantiomer of the ceramide ester XII. A positional isomer of XIII was obtained as a by-product. A novel technique in the Koenings-Knorr reaction is described. |
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