Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients |
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Authors: | Venetsanou Kyriaki Vlachos Konstantinos Moles Athanassios Fragakis Gerassimos Fildissis George Baltopoulos George |
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Institution: | Athens University School of Nursing Intensive Care and Research Unit, KAT General Hospital, Athens 14561, Greece. icuru@nurs.uoa.gr |
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Abstract: | Traumatic brain injury (TBI) acts as an inducer of the inflammatory reaction expressed by the release of pro-inflammatory cytokines (interleukin-1beta IL-1beta], interleukin-6 IL-6] and interleukin-8 IL-8]), and causes metabolic alterations in the early, post-traumatic state, either in the brain or/and the systemic circulation. The metabolic changes involve carbohydrates, proteins and lipids. We focused on the serum lipid profile, the impact of trauma on lipoproteins, and their subsequent effects, on inflammation. We investigated the role of cytokines and serum lipids, in patient outcome, reviewing 30-day mortality and the Glasgow Coma Scale (GCS). A total of 75 patients with severe or moderate TBI (GCS
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