A general approach toward the design of inhibitors of serine proteinases: inhibition of human leukocyte elastase by substituted dihydrouracils |
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| Authors: | William C. Groutas He Huang Jeffrey B. Epp Michael J. Brubaker Charles E. Keller Jerald J. McClenahan |
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| Affiliation: | Department of Chemistry Wichita State University Wichita, Kansas 67208 USA |
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| Abstract: | A general approach toward the rational design of potential inhibitors of serine proteinases is described. The approach is exemplified and validated through the use of appropriate heterocyclic systems in inhibiting human leukocytes elastase (HLE). |
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