| 冻干加热处理凝血因子类制剂的病毒灭活验证 |
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| 引用本文： | 王剑锋,英志芳,周铁群,邱平,陈震. 冻干加热处理凝血因子类制剂的病毒灭活验证[J]. 微生物学免疫学进展, 2005, 33(2): 29-31 |
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| 作者姓名： | 王剑锋 英志芳 周铁群 邱平 陈震 |
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| 作者单位： | 中国药品生物制品检定所,北京,100050 |
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| 摘 要： | 在病毒灭活验证过程中,比较了冻干后不同加热方法对凝血因子类制剂中伪狂犬病毒(PRV)的灭活效果,包括80℃干烤72h、100℃水浴加热30min以及100℃蒸汽加热30min方法。结果表明80℃干烤72h对制品中PRV灭活较彻底,另外两种方法对制品中PRV的灭活效果均不理想。
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| 关 键 词： | 凝血因子 病毒灭活 冻干 加热处理 |
| 文章编号： | 1005-5673(2005)02-0029-03 |
| 修稿时间： | 2004-11-08 |
Validation of virus inactivation in freeze-dried coagulation factors with heating treatment |
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| WANG Jian-feng,YING Zhi-fang,ZHOU Tie-qun,et al.. Validation of virus inactivation in freeze-dried coagulation factors with heating treatment[J]. Progress In Microbiology and Immunology, 2005, 33(2): 29-31 |
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| Authors: | WANG Jian-feng YING Zhi-fang ZHOU Tie-qun et al. |
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| Abstract: | To compare the pseudorabies virus (PRV) inactivation efficiency in freeze-dried coagulation factors by different methods of heating treatment . The results showed that the efficiency of PRV inactivation by 80℃ baking for 72hr is better than those by 100℃ waterbath treatment for 30min and 100℃ steam heating for 30min. |
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| Keywords: | Coagulation factors Virus inactivation Freeze-dried Heating treatment |
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