Natural resistance mechanisms may play a role in protection against chemical carcinogenesis |
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Authors: | Pnina Brodt Julius Gordon |
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Institution: | (1) Department of Surgery, Division of Surgical Research, McGill University, Donner Building, 740 Docteur Penfield Avenue, H3A 1A4 Montral, Quebec, Canada |
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Abstract: | Summary Mice deprived of B lymphocytes by the chronic administration of anti-IgM antibodies have been shown to possess a heightened natural resistance (NR) to micro-organisms, to parental bone marrow, and to natural killer (NK)-sensitive tumors in vitro and in vivo. Experiments described in this communication indicate that the latent period of primary tumors induced by the injection of methylcholanthrene (MC) is also prolonged in these mice. This observation suggests that NR mechanisms may provide protection against primary chemically induced tumors.
Abbreviations used in this paper: MC, methylcholanthrene; NR, natural resistance; NRG, normal rabbit serum pool; NK, natural killer cell |
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