IgG antibodies to Lewis type 2 antigens in serum of H. pylori-infected and noninfected blood donors of different Lewis(a,b) blood-group phenotype |
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Authors: | Oleg Kurtenkov Kersti Klaamas Ljudmila Miljukhina Ljudmila Shljapnikova Malle Ellamaa Nikolai Bovin Torkel Wadström |
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Institution: | Institute of Experimental and Clinical Medicine, Tallinn, Estonia. |
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Abstract: | Individuals of the Le(b+)/secretor phenotype revealed a stronger natural immune response to Le(x) and Le(y) epitopes irrespective of Helicobacter pylori serologic status. In contrast, H. pylori-infected Le(b-) type individuals showed a significantly higher proportion of strong responders to Le(x) antigen compared with the H. pylori-uninfected subgroup. The data suggest that the immune response to Lewis type 2 determinants is related to both the H. pylori serologic status and the Le(a,b) phenotype of the host. |
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Keywords: | Helicobacter pylori Lewis antigen Blood group antigen Immune response |
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