| 克柔念珠菌对抗真菌药物耐药机制的研究进展 |
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| 引用本文： | 乔祖莎,冯文莉.克柔念珠菌对抗真菌药物耐药机制的研究进展[J].中国真菌学杂志,2012,7(1):55-58. |
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| 作者姓名： | 乔祖莎 冯文莉 |
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| 作者单位： | 山西医科大学第二医院皮肤性病科,太原,030001 |
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| 基金项目： | 山西医科大学科技创新基金（01201013） |
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| 摘 要： | 近年来,克柔念珠菌感染明显增加,对抗真菌药物尤其是唑类药物的耐药现象越来越严重,深入研究其耐药机制已引起高度关注.克柔念珠菌耐药机制可能与以下因素有关:唑类药物作用靶酶结构的改变、真菌细胞膜上外排泵过度表达、真菌细胞内药物蓄积减少等.克柔念珠菌对唑类的耐药可能是多种耐药机制共同作用的结果.
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| 关 键 词： | 克柔念珠菌 抗真菌药 耐药 分子机制 |
Advances in research on mechanisms for drug resistance of Candida krusei |
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| QIAO Zu-sha
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FENG Wen-li.Advances in research on mechanisms for drug resistance of Candida krusei[J].Chinese JOurnal of Mycology,2012,7(1):55-58. |
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| Authors: | QIAO Zu-sha FENG Wen-li |
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| Institution: | (Department of Dermatovenereology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Invasive infections of Candida krusei increased in recent years contributed to the resistance to fuconazole.The mechanism of resistance in C.krusei may be a variety of drug-resistant possibilities including changed structure of cytochrome P450 sterol 14-demethylase in fungal cell,overexpression of efflux pumps,and reduced intracellular drug accumulation. |
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| Keywords: | Candida krusei antifungal drug drug resistant molecular mechanisms |
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