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Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists |
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| Authors: | Merriman Gregory H Ma Liang Shum Patrick McGarry Daniel Volz Frank Sabol Jeffrey S Gross Alexandre Zhao Zhicheng Rampe David Wang Lin Wirtz-Brugger Friederike Harris Bruce A Macdonald Douglas |
| Institution: | Aventis Inc., 1041 Route 202-206, Bridgewater, New Jersey, NJ 08807-0800, USA. gregory.merriman@aventis.com |
| Abstract: | A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described. |
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