Effect of Cavtratin,a Caveolin-1 Scaffolding Domain Peptide,on Oligodendroglial Signaling Cascades |
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Authors: | Matthias Schmitz Inga Zerr Hans H Althaus |
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Institution: | 1.Max-Planck Institute of Experimental Medicine, RU Neural Regeneration,G?ttingen,Germany;2.National TSE Reference Center, Department of Neurology,Georg-August University G?ttingen,G?ttingen,Germany |
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Abstract: | Caveolin and caveolin containing rafts are involved in the signaling of growth factors in various cell types. Previous reports
of our lab indicated a co-localization of caveolin and the high affinity nerve growth factor (NGF) receptor tyrosine kinase
A (TrkA). Mutual effects have been observed among which a caveolin-1 knock-down resulted in an impairment of the NGF signaling
cascade rather than in an increase of activity as expected from other growth factor reports. On the other hand, an over-expression
of caveolin-1 impaired the NGF stimulated activity of p42/44 mitogen activated protein kinases (MAPK). In this study, we used
a caveolin-1 scaffolding domain (CSD) peptide (cavtratin) of which an inhibitory effect on growth factor receptors was reported.
Our data showed that cavtratin suppresses the NGF-induced phosphorylation of TrkA as well as the activation of MAPK in porcine
oligodendrocytes significantly. |
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