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Isolation of 4-acetyl-benzoxazolin-2-one (4-ABOA) and diferuloylputrescine from an extract of gibberella ear rot-resistant corn that blocks mycotoxin biosynthesis, and the insect toxicity of 4-ABOA and related compounds |
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| Authors: | J David Miller David A Fielder Patrick F Dowd Robert A Norton F William Collins |
| Institution: | a Plant Research Centre, Agriculture and Agrifood Canada, Ottawa, Ontario K1A 0C6, Canada b National Center for Agricultural Utilization Research, USDA/ARS, 1815 N. University Street, Peoria, IL 61604-3999, U.S.A. c Centre for Food and Animal Research, Agriculture and Agrifood Canada, Ottawa, Ontario K1A 0C6, Canada |
| Abstract: | Bioassay-directed fractionation of an extract of a gibberella ear rot-resistant corn hybrid resulted in the isolation of a fraction that inhibited mycotoxin production, but not growth, of Fusarium culmorum. The fraction contained diferuloylputrescine and a new allelochemical 4-acetyl-benzoxazolin-2-one (4-ABOA). This report describes the isolation of the bioactive fraction and tests of the effect of 4-ABOA on 3-acetyl deoxynivalenol (3ADON) and aflatoxin production. In addition, data are reported on the effects of 4-ABOA and related compounds on a number of insect species and some preliminary studies on the mechanism of insect toxicity. The effect of 4-ABOA on F. culmorum and Apergillus flavus was similar. Production of toxin was reduced without a concomitant reduction of growth. A 50% inhibition of 3ADON production occurred at ca. 4 μM and 0.12 mM for alfatoxin. 4-ABOA was slightly toxic to Spodoptera frugiperda. |
| Keywords: | 4-ABOA diferuloylputrescine corn allelochemical aflatoxin deoxynivalenol Fusarium Aspergillus |
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