Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine |
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Authors: | Iwanaga Koji Takano Hiroyuki Ohtsuka Masashi Hasegawa Hiroshi Zou Yunzeng Qin Yingjie Odaka Kenichi Hiroshima Kenzo Tadokoro Hiroyuki Komuro Issei |
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Affiliation: | Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. |
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Abstract: | We examined whether granulocyte colony-stimulating factor (G-CSF) prevents cardiac dysfunction and remodeling after myocardial infarction (MI) in large animals. MI was produced by ligation of left anterior descending coronary artery in swine. G-CSF (10 microg/kg/day, once a day) was injected subcutaneously from 24h after ligation for 7 days. Echocardiographic examination revealed that the G-CSF treatment induced improvement of cardiac function and attenuation of cardiac remodeling at 4 weeks after MI. In the ischemic region, the number of apoptotic endothelial cells was smaller and the number of vessels was larger in the G-CSF treatment group than in control group. Moreover, vascular endothelial growth factor was more abundantly expressed and Akt was more strongly activated in the ischemic region of the G-CSF treatment group than of control group. These findings suggest that G-CSF prevents cardiac dysfunction and remodeling after MI in large animals. |
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Keywords: | Akt Angiogenesis Apoptosis Cytokine G-CSF Myocardial infarction Remodeling Swine VEGF |
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