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| 小鼠、大鼠、豚鼠和沙鼠对禽流感病毒致病敏感性的比较初报 | |
| 引用本文： | 李志东,刘忠华,陈美才,赵维波,廖明,黄韧. 小鼠、大鼠、豚鼠和沙鼠对禽流感病毒致病敏感性的比较初报[J]. 中国实验动物学报, 2004, 12(4): 212-214 |
| 作者姓名： | 李志东 刘忠华 陈美才 赵维波 廖明 黄韧 |
| 作者单位： | 1. 广东医学院,湛江,524023 2. 广东省实验动物监测所,广州,510260 3. 华南农业大学,广州,510642 |
| 摘 要： | 目的比较不同物种和品系的哺乳类实验动物对H5N1禽流感病毒(AIV)致病的敏感性。方法对不同动物经鼻腔接毒,然后通过体温、体重、临床症状、病理变化、病毒分离和抗体测定进行比较分析。结果在实验的4个不同物种共7个品系的哺乳动物中,小鼠对AIV较豚鼠、沙鼠和大鼠敏感。结论ICR和NIH小鼠适宜用来制作AIV感染的动物模型。 |
| 关 键 词： | 禽流感病毒 模型 动物 哺乳动物 致病力 |
| 文章编号： | 1005-4847(2004)04-0212-03 |
| 修稿时间： | 2004-05-09 |
The Comparison of Pathogenicity of Avian Influenza Virus to Mouse,Rat,Cavia Cobaya and Gerbil |
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| LI Zhi_dong ,LIU Zhong_hua ,CHEN Mei_cai ,ZHAO Wei_bo ,LIAO Ming ,HUANG Ren. The Comparison of Pathogenicity of Avian Influenza Virus to Mouse,Rat,Cavia Cobaya and Gerbil[J]. Acta Laboratorium Animalis Scientia Sinica, 2004, 12(4): 212-214 | |
| Authors: | LI Zhi_dong LIU Zhong_hua CHEN Mei_cai ZHAO Wei_bo LIAO Ming HUANG Ren |
| Affiliation: | LI Zhi_dong 1,LIU Zhong_hua 2,CHEN Mei_cai 1,ZHAO Wei_bo 1,LIAO Ming 3,HUANG Ren 2 |
| Abstract: | Objective To compare the pathogenicity of avian influenza virus to different mammals. Methods Four different species of mammal were selected, receiving the AIV through nasal cavity; then the changes of body temperature,body weight,clinical signs and pathology were observed, the virus from the experimental animals isolated and the antibody detected. Results Among mouse,rat,cavia cobaya and gerbil, mouse is the most sensitive animal model to AIV. Conclusion ICR and NIH mouse are suitable animal models for Avian influenza infection. |
| Keywords: | Avian Influenza Virus Models animal Mammals Pathogenicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |