The role of extracellular vesicles in endometrial receptivity and their potential in reproductive therapeutics and diagnosis |
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| Affiliation: | 1. Academic Unit of Reproductive and Developmental Medicine, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK;2. Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Malaysia;3. Department of Pathophysiology, Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, 14B Ravila, 50411 Tartu, Estonia;4. Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia;5. SPD Development Company Ltd, Clearblue Innovation Centre, Stannard Way, Priory Business Park, Bedford MK44 3UP, UK;6. Department of neuroscience, University of Sheffield, Sheffield, UK;1. Department of Laboratory, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China;2. Department of Gynecology, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China;1. Department of Obstetrics, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan Hubei Province 430015, China;2. Department of Pathology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan Hubei Province 430015, China;1. Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China;2. Reproductive Medicine Centre, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China;1. Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland;2. Forensic Genetics Section, Institute of Forensic Research, Krakow, Poland;3. Deptartment of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland;4. Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany;5. Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences Jastrz?biec, Magdalenka, Poland;1. Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Switzerland;2. Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Egypt;3. Gestüt Lewitz, Neustadt-Glewe, Germany;4. Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Switzerland;1. Animal Science, School of Agricultural Sciences, Southern Illinois University, Carbondale, IL, USA;2. Department of Animal Science, Federal University of Viçosa, Viçosa, MG, Brazil;3. Department of Veterinary, Federal University of Viçosa, Viçosa, MG, Brazil |
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| Abstract: | Extracellular vesicles (EVs) are small, nanometre sized, membrane-enclosed structures released by cells and are thought to be crucial in cellular communication. The cargo of these vesicles includes lipids, proteins, RNAs and DNA, and control various biological processes in their target tissues depending on the parental and receiver cell’s origin and phenotype. Recently data has accumulated in the role of EVs in embryo implantation and pregnancy, with EVs identified in the uterine cavity of women, sheep, cows, horses, and mice, in which they aid blastocyst and endometrial preparation for implantation. Herein is a critical review to decipher the role of extracellular vesicles in endometrial receptivity and their potential in reproductive therapies and diagnosis. The current knowledge of the function of embryo and endometrial derived EVs and their cargoes, with regards to their effect on implantation and receptivity are summarized and evaluated. The findings of the below review highlight that the combined knowledge on EVs deriving from the endometrium and embryo have the potential to be translated to various clinical applications including treatment, a diagnostic biomarker for diseases and a drug delivery tool to ultimately improve pregnancy rates. |
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| Keywords: | Extracellular vesicles Embryo Endometrium Reproduction Treatment Diagnosis |
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