The composition,function, and regulation of adipose stem and progenitor cells |
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| Institution: | 1. National Clinical Research Center for Metabolic Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China;2. Key Laboratory of Diabetes Immunology, Ministry of Education, and Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China;3. Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;4. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan 410008, China;5. Clinical Immunology Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China;1. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;2. University of Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China;3. CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China;4. Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK;5. CAS Center of Excellence for Animal Evolution and Genetics, Kunming, Yunnan 650223, China;1. National Clinical Research Center for Child Health of the Children''s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China;2. Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;3. Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China;1. Metabolic Disease Research Center, Zhengzhou University Affiliated Zhengzhou Central Hospital, Zhengzhou, Henan 450007, China;2. Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China;3. Center for Advanced Medicine, College of Medicine, Zhengzhou University, Zhengzhou, Henan 450007, China;4. Department of Orthopedics, Zhengzhou Central Hospital, Zhengzhou, Henan 450000, China |
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| Abstract: | White adipose tissue (WAT) is a highly plastic organ that plays a central role in regulating whole-body energy metabolism. Adipose stem and progenitor cells (ASPCs) are essential components of the stromal vascular fraction (SVF) of adipose tissue. They give rise to mature adipocytes and play a critical role in maintaining adipose tissue function. However, the molecular heterogeneity and functional diversity of ASPCs are still poorly understood. Recently, single-cell RNA sequencing (scRNA-seq) analysis has identified distinct subtypes of ASPCs in murine and human adipose tissues, providing new insights into the cellular complexity of ASPCs among multiple fat depots. This review summarizes the current knowledge on ASPC populations, including their markers, functions, and regulatory mechanisms. Targeting one or several of these cell populations may ameliorate metabolic disorders by promoting adaptive hyperplastic adipose growth. |
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| Keywords: | Adipose tissue ASPCs scRNA-seq Committed preadipocytes Regulatory progenitors |
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