Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions |
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| Affiliation: | 1. Center for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;1. National Clinical Research Center for Child Health of the Children''s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China;2. Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;3. Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China |
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| Abstract: | Coat protein complex II (COPII)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum (ER) to different destinations. cTAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPII carrier and cargo trafficking through direct or indirect interaction with COPII components. cTAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions. |
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| Keywords: | cTAGE5/MEA6 COPII ER Cargo secretion |
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