Effects of tamoxifen on the electron transport chain of isolated rat liver mitochondria |
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Authors: | C Tuquet J Dupont A Mesneau J Roussaux |
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Institution: | (1) Laboratoire de Biologie Cellulaire Végétale, Université Pierre et Marie Curie, Paris, France |
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Abstract: | Tamoxifen (and 4-hydroxytamoxifen), a nonsteroidal triphenylethylene antiestrogenic drug widely used in the treatment of breast
cancer, interacts strongly with the respiratory chain of isolated rat liver mitochondria. The drug acts as both an uncoupling
agent and a powerful inhibitor of electron transport. Tamoxifen brings about a collapse of the membrane potential. Enzymatic
assays and spectroscopic studies indicate that tamoxifen inhibits electron transfer in the respiratory chain at the levels
of complex III (ubiquinol–cytochrome-c reductase) and, to a lesser extent, of complex IV (cytochrome-c oxidase). The activities can be restored by the addition of diphosphatidylglycerol, a phospholipid implicated in the functioning
of the respiratory chain complexes.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | electron transport chain isolated mitochondria rat liver tamoxifen |
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