静注丙球低pH孵放灭活病毒效果验证 |
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引用本文: | 周铁群,王剑锋,邱平,沈月雷. 静注丙球低pH孵放灭活病毒效果验证[J]. 微生物学免疫学进展, 1998, 0(1) |
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作者姓名: | 周铁群 王剑锋 邱平 沈月雷 |
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作者单位: | 中国药品生物制品检定所 |
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摘 要: | 以水泡性口炎病毒(VSV)为指示病毒,考察了低pH孵放不同时间对低温乙醇法生产的静注丙球(IVIG)中VSV的灭活效果,并对不同厂家及不同批号IVIG中病毒灭活情况进行了比较。结果表明,液体IVIG在PH4.1±0.3,20-25℃,孵放21天可灭活VSV达6Logs以上(即低于实验检测限),但不同厂家及不同批号的IVIG在病毒灭活的发生上有所不同
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关 键 词: | 静注丙球(IVIG) 水泡性口炎病毒(VSV) 低PH 病毒灭活 |
Virus Inactivation in Low pH Intraveneous Immunoglobulin |
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Abstract: | Effects of low pH incubation (pH4.1±0.3,20-25℃,21 days) on inactivation of lipid envelope marker virus,vesicular stomatitis virus (VSV) in the production process of intraveneous immunoglobulin (IVIG) were investigated on a laboratory scale. The results showed that the highest inactivation capacity in such circumstances for VSV was more than 6 Logs (under detection limit) and that the occurrence of VSV inactivation was different in IVIG produced by different manufacturer. |
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Keywords: | Intraveneous Immunoglobulin (IVIG) Vesicular Stomatitis (VSV) Low pH Virus Inactivation |
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