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Wnt signaling: Ig-norrin the dogma |
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| Authors: | Clevers Hans |
| Institution: | Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. clevers@niob.knaw.nl |
| Abstract: | Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome. |
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