Effect of selenite treatment on ultrastructural changes in experimental diabetic rat bones |
| |
Authors: | Semir Ozdemir Murat Ayaz Belgin Can Belma Turan |
| |
Institution: | (1) Department of Biophysics School of Medicine, Ankara University, 06100 Ankara, Turkey;(2) Department of Histology-Embryology, School of Medicine, Ankara University, 06100 Ankara, Turkey |
| |
Abstract: | It is known that streptozotocin (STZ)-induced diabetes causes functional and structural alterations in some types of tissue
and organ. A number of methods have been used to characterize the properties of diabetic tissues and their diagnosis. Selenium
compounds, playing an antioxidant role, can restore some altered metabolic parameters and diminished functions in experimental
diabetes. The first aim of the present study was to investigate the effects of STZ-induced diabetes on structural properties
of rat long bones. Electron and light microscopic observations showed deleterious alterations in the structure of the diabetic
rat long bones, the most prominent effect being in osteocytic cells. Fine cytoplasmic processes of the osteocytes seemed to
be shortened, and diabetes affected the normal cytoplasmic processes in a negative manner. The second aim of the present study
was to evaluate the effects of sodium selenite treatment for 4 wk on the long bones of the diabetic rats. Electron and light
microscopic observations demonstrated that sodium selenite treatment prevented the STZ-induced structural as well as ultrastructural
changes in the long bones of the rats. In conclusion, this study first showed that a period of 5-wk diabetes was enough to
cause some important and degenerative changes in the structure of the bone tissues, and, second, it demonstrated that sodium
selenite treatment of the diabetic rats could normalize these alterations. |
| |
Keywords: | Sodium selenite femur oxidant stress electron microscopy diabetes antioxidant |
本文献已被 PubMed SpringerLink 等数据库收录! |
|