Amino Acids from <Emphasis Type="Italic">Mytilus galloprovincialis</Emphasis> (L.) and <Emphasis Type="Italic">Rapana venosa</Emphasis> Molluscs Accelerate Skin Wounds Healing via Enhancement of Dermal and Epidermal Neoformation |
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| Authors: | Diana L Badiu Rafael Luque Elena Dumitrescu Anca Craciun Danut Dinca |
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| Institution: | (1) Department of Biology-Biochemistry, Faculty of Natural and Agricultural Sciences, Ovidius University of Constanta, 124 Mamaia Blvd., 900527 Constanta, Romania;(2) Departament of Organic Chemistry, Cordoba University, Campus de Rabanales, Edificio Marie Curie (C-3), Ctra Nnal IV, Km 396, 14004 Cordoba, Spain;(3) National Institute of Recovery, Physical Medicine and Clinical Balneary, 11 A, Ion Mihalache Blvd., Bucharest, Romania;(4) Phatological Anatomy Laboratory, Constanta Clinical Emergency Hospital, 145 Tomis Blvd, 900591 Constanta, Romania;(5) Otorhinolaryngology Department, Constanta Clinical Emergency Hospital, 145 Tomis Blvd., 900591 Constanta, Romania |
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| Abstract: | Wound healing consists of re-epithelialization, contraction and formation of granulation and scar tissue. Amino acids from
proteins are involved in these events, but their exact roles are not well understood. The present study was undertaken to
investigate the anti-inflammatory effects of some amino acids from two molluscs, Mytilus galloprovincialis (L.) (Mediterranean mussel) and Rapana venosa (hard shell-clam) employed in induced skin burn injuries in Wistar rats. The treatment was evaluated in terms of essential
amino acids composition which rendered the extracts very efficient in healing skin burns. The healing process was examined
by periodic acid Schiff’s, Verhoeff’s Van Gieson and immunohistochemistry stains for collagen IV, CD 34 and CD 117 antibodies.
According to the obtained results, as expressed by histological studies, the most abundant blood vessels, collagen fibres,
basal and stem cells were found only for treated animals with amino acids from Rapana venosa extracts. The rich composition of amino acids from the two molluscs merits consideration as therapeutic agents in the treatment
of skin burns. |
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