A kinesin motor in a force-producing conformation |
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Authors: | Elisabeth Heuston C Eric Bronner F Jon Kull Sharyn A Endow |
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Affiliation: | (1) Department of Chemistry, Dartmouth College, 03755 Hanover, NH, USA;(2) Department of Cell Biology, Duke University, 27710 Durham, NC, USA |
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Abstract: | Background Kinesin motors hydrolyze ATP to produce force and move along microtubules, converting chemical energy into work by a mechanism that is only poorly understood. Key transitions and intermediate states in the process are still structurally uncharacterized, and remain outstanding questions in the field. Perturbing the motor by introducing point mutations could stabilize transitional or unstable states, providing critical information about these rarer states. |
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