Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping. |
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| Authors: | W J Brouillette V R Atigadda M Luo G M Air Y S Babu S Bantia |
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| Affiliation: | Department of Chemistry, University of Alabama at Birmingham, 35294, USA. |
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| Abstract: | A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors. |
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