Hypermethioninemia provokes oxidative damage and histological changes in liver of rats |
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| Authors: | Francieli M. Stefanello,Cristiane Matté ,Carolina D. Pederzolli,Janaí na Kolling,Caroline P. Mescka,Marcelo L. Lamers,Adriano M. de Assis,Marcos L. Perry,Marinilce F. dos Santos,Carlos S. Dutra-Filho,Angela T.S. Wyse |
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| Affiliation: | 1. Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, CEP 90035-003, Porto Alegre, RS, Brazil;2. Departamento de Biologia Celular e do Desenvolvimento, ICB, Universidade de São Paulo, Avenida Prof. Lineu Prestes, 1524 – CEP 05508-000, São Paulo, SP, Brazil |
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| Abstract: | In the present study we evaluated the effect of chronic methionine administration on oxidative stress and biochemical parameters in liver and serum of rats, respectively. We also performed histological analysis in liver. Results showed that hypermethioninemia increased chemiluminescence, carbonyl content and glutathione peroxidase activity, decreased total antioxidant potential, as well as altered catalase activity. Hypermethioninemia increased synthesis and concentration of glycogen, besides histological studies showed morphological alterations and reduction in the glycogen/glycoprotein content in liver. Serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and glucose were increased in hypermethioninemic rats. These findings suggest that oxidative damage and histological changes caused by methionine may be related to the hepatic injury observed in hypermethioninemia. |
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| Keywords: | Hypermethioninemia Oxidative stress Histological changes Glycogen content Liver Serum |
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