Structure and substrate specificity of acetyltransferase ACIAD1637 from Acinetobacter baylyi ADP1 |
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| Authors: | Anna M Davies Renée TataAlison Snape Brian J SuttonPaul R Brown |
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| Institution: | King''s College London, Randall Division of Cell and Molecular Biophysics, London, SE1 1UL, UK |
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| Abstract: | Gene ACIAD1637 from Acinetobacter baylyi ADP1 encodes a 182 amino acid putative antibiotic resistance protein. The structure of this protein (termed acepita) has been solved in space group P2 to 2.35 Å resolution. Acepita belongs to the GCN5-related N-acetyltransferase (GNAT) family, and contains the four sequence motifs conserved among family members. The structure of acepita is compared with that of pita, its homologue from Pseudomonas aeruginosa. Acepita has a similar substrate profile to pita and performs a similar function. |
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| Keywords: | GNAT Acetyltransferase Methionine sulfoximine Phosphinothricin |
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