Internalization-defective mutants of somatostatin receptor subtype 2 exert normal signaling functions in hematopoietic cells |
| |
Authors: | Oomen S P Hofland L J Lamberts S W Löwenberg B Touw I P |
| |
Affiliation: | Institute of Hematology, Erasmus University Rotterdam, The Netherlands. |
| |
Abstract: | The regulatory peptide somatostatin (SST) acts via a family of G-protein-coupled receptors comprising five subtypes (SSTR1-5). G-protein-coupled receptors activate multiple signaling mechanisms, which variably depend on internalization and intracellular routing of activated receptors. We have recently demonstrated that hematopoietic precursors express SSTR2 and that SST is a chemoattractant for these cells. Herein, we characterize critical regions in SSTR2 involved in endocytosis and describe how ligand-induced internalization impacts on two major signaling functions of SSTR2 in hematopoietic cells, the activation of the Erk pathway and the induction of promigratory responses. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|