Effects of anti-triadin antibody on Ca2+ release from sarcoplasmic reticulum. |
| |
| Authors: | N R Brandt A H Caswell J P Brunschwig J J Kang B Antoniu N Ikemoto |
| |
| Affiliation: | Department of Pharmacology, University of Miami School of Medicine, FL 33101. |
| |
| Abstract: | The monoclonal antibody, mAb GE 4.90, raised against triadin, a 95 kDa protein of sarcoplasmic reticulum (SR), inhibits the slow phase of Ca2+ release from SR following depolarization of the T-tubule moiety of the triad. The antibody has virtually no effect on the fast phase of depolarization-induced Ca2+ release nor on caffeine-induced Ca2+ release. Since the slow phase of depolarization-induced Ca2+ release is also inhibited by dihydropyridines (DHP), these results suggest that triadin may be involved in the functional coupling between the DHP receptor and the SR Ca2+ channel. |
| |
| Keywords: | |
|
|
