Genetic and Molecular Characterization of New Natural Haplotype t
wMP1 Found in House Mouse Mus domesticus R. from Peru |
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Authors: | L D Safronova I V Shustrova |
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Institution: | (1) Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071, Russia |
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Abstract: | A new natural haplotype, t
wMP1, found in a population of house mouse Mus domesticus from Peru, was subjected to genetic and molecular analyses. Experiments were performed to study the complementation of the new haplotype, fertility of t
wMP1/t
x heterozygotes, and transmission ratio distortion (TRD) of the t-carrying chromosome in the progeny of heterozygous males. Molecular analysis included blot hybridization with t-specific probes Tu48, Tu66, and Tu119. The results were collated with the structure and properties of the t complex, and the new haplotype was identified as a complete lethal one. |
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