Fluorinated quinoid inhibitor: possible "pure" arylator predicted by the simple theoretical calculation |
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| Authors: | Ham Seung Wook Choe Jong-In Wang Mei-Fang Peyregne Vincent Carr Brian I |
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| Affiliation: | Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. |
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| Abstract: | We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species. |
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