具减肥功效的益生菌研究进展

摘要：肥胖症患病率在全球范围内持续增长，其中导致肥胖的最主要因素是能量摄入和消耗失衡。肠道菌群是涉及肥胖和代谢紊乱的环境因素，肥胖动物和人类患者表现出了肠道菌群组成和结构的改变。这种菌群失衡能影响机体能量平衡、炎症和肠道屏障功能等，进而影响代谢。研究显示益生菌可有效改善高脂饮食造成的肥胖。改变肠道菌群可能会成为预防或控制肥胖的有效疗法，该领域尚处于早期阶段，相关数据仍有限。本综述旨在总结最新的具有减肥功效益生菌的实验研究，帮助了解减肥益生菌的最新进展，为该领域后续研究提供帮助。

Progress in research on probiotics in treatment of obesity

Abstract: Obesity is a growing epidemic worldwide. The most frequent cause leading to the development of obesity is an imbalance between energy intake and energy expenditure. Gut microbiota is an environmental factor involved in obesity and metabolic disorders which reveals that obese animal and human subjects present alterations in the composition of gut microbiota. Recent studies have shown that intestinal microbiota is a potential determinant of obesity. Evidence has so far demonstrated that gut microbiota, which influences whole-body metabolisms by affecting energy balance, inflammation and gut barrier function, can alter body weight. In the meantime, emerging evidence reveals that species of intestinal commensal bacteria play an important role in the treatment of obesity. Therefore targeting gut microbiota provides an effective treatment and prevention for obesity. However, the available data in this field remain limited. This review summarizes cutting-edge research on probiotics in treatment for obesity, existing issues in treatment with probiotics, and the future prospect of probiotics.