降血糖药物治疗对糖尿病动物模型及患者肠道菌群的影响

随着人们生活方式和饮食结构的改变,我国糖尿病的发病率呈逐年上升趋势。如何预防并有效治疗糖尿病成为医疗工作者们重要的研究课题。目前,药物治疗是糖尿病最常用、安全以及经济的治疗手段。近年来,肠道菌群成为人们研究的焦点,越来越多证据表明它与糖尿病的发生发展存在密切的联系。本文总结了双胍类、噻唑烷二酮胰岛素增敏剂类、α糖苷酶抑制剂类、二肽基肽酶-4抑制剂(DPP-4)和胰高血糖素样肽-1(GLP-1)类似物、促胰岛素分泌剂和中药及其制剂等降血糖药物对糖尿病动物模型及患者肠道菌群的影响,以期为糖尿病的预测、预防及治疗提供参考。

Effect of antidiabetic medication on intestinal microbiota in animal models and diabetes patients

Abstract: Along with the changes of dietary structure and lifestyle, the incidence of diabetes is increasing year by year in China. The prevention and effective treatment of diabetes have become a very important research topic. At present, medicines are the most commonly-used, safe and economical means of treating diabetes. In recent years, intestinal flora has become a research focus for scholars. More and more evidences indicated that it is closely related to the occurrence and development of diabetes. In this paper, the effects of biguanide, thiazolidinedione, alphaglucosidase inhibitor, DPP-4, GLP-1 and traditional Chinese medicine on intestinal microbiota in animal models and diabetes patients were summarized.