老年房颤患者肠道菌群变化及其影响因素

目的 探讨老年房颤患者肠道菌群变化及影响菌群变化的相关因素。 方法 回顾性收集20例老年房颤患者作为房颤组,并选取性别、年龄与患者匹配的30例老年健康体检者作为对照组,分析两组对象肠道优势菌的特点。同时收集房颤组患者C反应蛋白(CRP)、总胆汁酸(TBA)、同型半胱氨酸(Hcy)、B型纳尿肽(BNP)、左室射血分数数值(LVEF)等检测结果,分析上述因素与肠道优势菌群的关系。 结果 房颤组患者直肠真杆菌数量为(4.66±1.62)lg copies/g粪便,低于对照组的(6.10±1.44)lg copies/g粪便,差异有统计学意义(t=-3.286,P=0.002)。房颤组患者肠道普拉梭菌、肠球菌、类杆菌、乳杆菌、双歧杆菌、柔嫩梭菌、酪酸梭菌、Atopobium cluster(Ato)、肠杆菌数量及双歧杆菌/肠杆菌(B/E)值与对照组比较差异无统计学意义(均P>0.05)。在房颤组中,CRP升高患者肠道双歧杆菌数量和B/E值显著高于CRP正常患者,CRP升高与双歧杆菌数量呈正相关(r=0.651,P=0.002)；Hcy升高患者肠道肠杆菌数量显著高于Hcy正常患者,Hcy升高与肠杆菌数量呈正相关(r=0.567,P=0.009)。BNP、TBA、LVEF与优势菌群无显著相关性。 结论 老年房颤患者存在肠道菌群失调。CRP、Hcy和老年房颤患者肠道菌群具有一定的相关性。

Changes of gut microbes and its related factors in gerontal atrial fibrillation patients

Objective To observe the changes of gut microbes in gerontal atrial fibrillation (AF) patients and explore the related factors. Methods A total of 20 gerontal AF patients were enrolled as AF group. Age and gendermatched healthy aged individuals were selected as control group. The gut microbes were analyzed in both groups. The levels of C reactive protein (CRP), total bile acid (TBA), homocysteine (Hcy), brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF) were recorded, and the relationship between these factors and gut microbes were analyzed. Results The number of Eubacterium rectale was (4.66±1.62) lg copies/g feces in AF group, significantly lower than the (6.10±1.44) lg copies/g feces in control group (t=3.286, P=0.002). There were no significant differences in Clostridium planum, Enterococcus, Bacteroides, Lactobacillus, Bifidobacterium, Clostridium leptum, Clostridium caseate, Atopobium cluster (Ato), Enterobacter and Bifidobacterium/Enterobacter ratio (B/E) between groups (all P>0.05). In AF group, patients with high CRP level had higher number of Bifidobacterium and B/E than those with normal CRP (all PConclusion Imbalance of gut microbes exists in gerontal AF patients. CRP and Hcy may be associated with the changes of gut microbes in gerontal AF patients.