一种益生菌组合的降胆固醇能力研究 |
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引用本文: | 李晓军,马跃英,龚虹,冯谦,王春颖,李康宁,黄少磊,刘彦民.一种益生菌组合的降胆固醇能力研究[J].中国微生态学杂志,2017,29(6). |
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作者姓名: | 李晓军 马跃英 龚虹 冯谦 王春颖 李康宁 黄少磊 刘彦民 |
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作者单位: | 内蒙古双奇药业股份有限公司,内蒙古双奇药业股份有限公司,内蒙古双奇药业股份有限公司,内蒙古双奇药业股份有限公司,内蒙古双奇药业股份有限公司,内蒙古双奇药业股份有限公司,内蒙古双奇药业股份有限公司,内蒙古双奇药业股份有限公司 |
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摘 要: | 目的 研究一种由乳双歧杆菌HN019和鼠李糖乳杆菌HN001构成的益生菌组合的降胆固醇能力。方法 分别采用体外测定胆固醇脱除率和灌胃高脂模型大鼠的方法,考察该益生菌组合物的降胆固醇能力。结果 该益生菌组合物体外的胆固醇脱除率达到78.82%,能够显著降低高脂模型大鼠的血清总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C),且差异有统计学意义(P<0.01)。该组合物的降胆固醇能力均优于单一菌株。结论 该益生菌组合物具有较强的降胆固醇能力,可考虑进一步开发为降胆固醇微生态制剂或保健食品。
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关 键 词: | 益生菌组合 降胆固醇 高脂模型 乳双歧杆菌HN019 鼠李糖乳杆菌HN001 |
The cholesterol-reducing ability of a probiotic combination |
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Abstract: | Objective To explore the cholesterol-reducing ability of a probiotic combination which consists of Bifidobacterium animalis subsp.lactis HN019 and Lactobacillus rhamnosus HN001. Methods High fat models of rat were established by using intragastric administration, and cholesterol removal rate was determined in vitro. Results The cholesterol removal rate of the probiotic combination reached 78.82% in vitro, and it significantly reduced the levels of TC, TG and LDL-C of high fat model rats (P<0.01), superior to that of single probiotic strain. Conclusion The tested probiotic composition has a strong ability to reduce cholesterol, which has a potential to be further developed into a cholesterol lowering microecological agent or health food. |
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Keywords: | Probiotic combination Cholesterol lowering High fat model Bifidobacterium animalis subsp lactis HN019 Lactobacillus rhamnosus HN001 |
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