待孕夫妇乙肝表面抗原及乙肝表面抗体阳性情况分析

目的 分析与探讨待孕夫妇乙肝表面抗原及乙肝表面抗体检测结果，并研究其对临床孕前检查的影响及评价。方法 随机选取2015‒2017年度在我院进行孕前检查的夫妇2440对（4 880例）为研究对象，按照年度将待孕夫妇分为两组，每组2 440例，两组均加强孕前检查中的乙肝表面抗原（HBsAg）及乙肝表面抗体（HBsAb）的检测。A组为2015年3月‒2016年2月在我院进行乙肝表面抗原及乙肝表面抗体检查的待孕夫妇；B组为2016年3月‒2017年2月在我院进行乙肝表面抗原及乙肝表面抗体检查的待孕夫妇。比较两组待孕夫妇乙肝表面抗原及乙肝表面抗体检测的阳性结果。结果 B组HBsAg阳性率、HBsAb阳性率明显高于A组（6.43% vs 4.63%；62.99% vs 58.44%），差异有统计学意义（P＜0.05）。B组、A组男性HBsAg阳性率明显高于同组女性（59.87% vs 40.13%；60.18% vs 39.82%），HBsAb阳性率低于同组女性（46.52% vs 53.48%；47.41% vs 52.59%），差异均有统计学意义（P＜0.05）。B组、A组高中及以上学历HBsAg阳性率明显低于同组高中以下学历（38.85% vs 61.95%；38.05% vs 61.15%），高中及以上学历HBsAb阳性率高于同组高中以下学历（53.15% vs 46.84%；51.75% vs 48.25%），差异均有统计学意义（P＜0.05）结论 目前夫妇乙肝感染仍处于增高趋势，对于进行孕前检查的待孕夫妇加强乙肝表面抗原及乙肝表面抗体的检测，有助于疾病的早期诊断、干预及治疗，能够减少乙肝传播，可有效降低新生儿乙肝发病率，促进优生优育，提高出生人口整体素质。

Analysis of hepatitis B surface antigen and hepatitis B surface antibody positive in pregnant couple

Objective To analyze and explore the results of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) test, and study its effect and evaluation on clinical pre-pregnancy examination. Methods 4,880 cases pregnant couple who received pre-pregnancy examination in our hospital from 2015 to 2017 were selected as the research subjects, and divided into two groups randomly, with 2,440 cases in each group. Both two groups were tested for HBsAg and HbsAb during pre-pregnancy examination. The preganat couple who received HBsAg and HbsAb test in our hospital from March 2015 to February 2016 were included into the group A, and the pregnant couple who received HBsAg and HbsAb test in our hospital from March 2016 to February 2017 were included into the group B. The positive result of HBsAg and HbsAb test were compared between two groups. Results The positive rates of HbsAg (6.43%) and HbsAb (62.99%) in the group B were significantly higher than the positive rates of HbsAg (4.63%) and HbsAb (58.44%) in the group A, and the differences were statistically significant (P<0.05). The positive rate of HbsAg in male of the group B (59.87%) was significantly higher than that in female of the group B (40.13%), the positive rate of HbsAb in male (46.52%) was lower than that in female (53.48%); The positive rate of HbsAg in male of the group A (60.18%) was significantly higher than that in female of the group A (39.82%), the positive rate of HbsAb in male (47.41%) was lower than that in female (52.59%), and the difference were statistically significant (P<0.05). The positive rates of HbsAg of patients with the education of high school and above in group B (38.85%) was significantly lower than the positive rates of HbsAg of patients with edication of lower than high school in group B (61.95%), the positive rates of HbsAb of patients with the education of high school and above (53.15%) was higher than the positive rates of HbsAg of patients with edication of lower than high school (46.84%); The positive rates of HbsAg of patients with the education of high school and above in group A (38.05%) was significantly lower than the positive rates of HbsAg of patients with edication of lower than high school in group A (61.15%), the positive rates of HbsAb of patients with the education of high school and above (51.75%) was higher than the positive rates of HbsAb of patients with edication of lower than high school (48.25%), and the differences were statistically significant (P<0.05). Conclusion At present, the infection of hepatitis B in our city is still increasing. The enhancement of HBsAg and HbsAb test in pregnant couples who received pre-pregnancy examination is helpful for the early diagnosis, intervention and treatment, reduce the spread of hepatitis B, and can effectively reduce the incidence of neonatal hepatitis B, promote better prenatal and postnatal care, and improve the overall quality of the birth population.