应用益生菌对代谢综合征患者干预效果的系统评价

目的系统评价应用益生菌对代谢综合征患者干预的效果。方法应用计算机检索Web of Science、PubMed、Cochrane Library、EMBASE、中国知网、维普、万方和CBM数据库中应用益生菌干预代谢综合征患者的随机对照试验,对纳入文献采用Cochrane Handbook(5.1.0)进行质量评价,采用RevMan 5.3软件进行Meta分析。结果共纳入9项研究。评价结果为口服益生菌可以降低代谢综合征患者腰围MD=-2.39,95%CI(-4.58,-0.19),P=0.03]和低密度脂蛋白水平SMD=-0.41,95%CI(-0.78,-0.04),P=0.03],在一定程度上改善胰岛素抵抗水平,但对空腹血糖水平SMD=-0.03,95%CI(-0.31,0.24),P=0.83]没有影响。结论应用益生菌干预代谢综合征患者可产生减肥效果,同时在一定程度上改善代谢综合征患者糖代谢紊乱状态,调节脂质代谢水平。但未来仍需要本土化、大样本、高质量的研究进一步探索益生菌干预代谢综合征患者的效果及最有效方案。

The effects of probiotics supplementation in patients with metabolic syndrome:a systematic review

Objective To systematically evaluate the effects of probiotics supplementation in patients with metabolic syndrome. Methods We searched databases including Web of Science, PubMed, Cochrane Library, EMBASE, CNKI, VIP, WanFang and CBM database, and included all the randomized controlled trials which used probiotics in patients with metabolic syndrome. The quality of literatures was evaluated with the Cochrane Handbook(5.1.0), and RevMan 5.3 software was used to analyze the data. Results A total of 9 studies were included. The results showed that oral probiotics could lower the waist circumference MD=-2.39, 95% CI(-4.58,-0.19), P=0.03] and low density lipoprotein levels SMD=-0.41, 95% CI(-0.78, 0.04), P=0.03] in patients with metabolic syndrome, and improve insulin resistance to some extent, but had no effect on fasting glucose level SMD=-0.03, 95% CI(-0.31, 0.24), P=0.83]. Conclusion Probiotics can help patients with metabolic syndrome lose weight, reduce insulin resistance and low density lipoprotein levels. They can also improve, to some extent, the disorder of glucose metabolism and regulate lipid metabolism of the patients. However, localized, large-sample and high-quality studies are still needed in the future to further explore the effect of probiotics and the most effective program for the intervention of metabolic syndrome.