树突状细胞与Toll受体研究新进展

树突状细胞是最强的抗原提呈细胞，在免疫系统中发挥着着重要作用。Toll样受体是表达在树突状细胞上的一种PRRs，主要功能是通过识别病原体微生物所携带的病原相关分子模式激活DC，使其分泌各种免疫调节细胞因子，从而启动免疫应答。在肠道免疫中TLR信号的激活为肠道提供保护作用。本文简述了树突状细胞的生物特性、不同亚型。重点阐述了Toll样受体在肠道免疫中的作用及益生菌对肠道Toll样受体表达的影响。

Recent progress in research on dendritic cells and Toll-like receptors

Dendritic cells are the strongest antigen-presenting cells，which play a key role in the immune system．As pattern recognition receptors，toll-like receptors are expressed on the dendritic cells，which can activate dendritic cells and immune response through recognizing the pathogen associated molecular patterns of pathogens．The activation of toll-like receptors plays a protective role within the gut．This paper briefly discusses the biological characteristics and different subtypes of dendritic cells．In this review，we will focus on the role played by TLRs in intestinal immunity and their crosstalk with probiotics．