2014—2016年某院铜绿假单胞菌耐药性监测

摘要：目的 分析铜绿假单胞菌的分布和耐药性变化，为临床防治铜绿假单胞菌感染提供依据。方法 收集成都大学附属医院2014—2016年所分离的铜绿假单胞菌，采用VITEK 2-Compact全自动细菌鉴定系统进行鉴定和药敏试验，采用WHONET 5.6软件对数据进行分析。结果 3年间共分离出1 945株铜绿假单胞菌，多重耐药铜绿假单胞菌分离率为34.2%（666/1945）。标本来源以呼吸道为主，占82.2%（1598/1945）。科室分布以呼吸内科最多，ICU其次。铜绿假单胞菌对头孢曲松和头孢噻肟的耐药率最高，均＞57.0%；对阿米卡星耐药率最低，为2.0%。3年来铜绿假单胞菌对17种抗生素的耐药率呈整体上升的趋势。结论 铜绿假单胞菌对头孢曲松、头孢噻肟、亚胺培南耐药率较高，对阿米卡星耐药率较低。铜绿假单胞菌的耐药率呈整体上升的趋势，应重视细菌耐药性的监测，以延缓耐药性产生、促进临床合理用药。

Resistance monitoring of Pseudomonas aeruginosa during 2014 - 2016

Abstract: Objective To investigate the distribution and drug resistance of Pseudomonas aeruginosa, and provide reference for the prevention and control of P. aeruginosa. Methods Samples were isolated in the affiliated hospital of Chengdu University from 2014 to 2016. The bacterial identification and susceptibility analysis of P. aeruginosa were carried out by using VITEK 2-Compact. The result was analyzed by using WHONET 5.6. Results A total of 1,945 strains of P. aeruginosa were isolated, among which 666 isolates were multi-drug resistant. The specimens were isolated mainly from respiratory tract (82.2%). P. aeruginosa were mainly found in the department of respiratory medicine and ICU. The resistance rate to Ceftriaxone and Cefotaxime of P. aeruginosa were the highest, over 57.0% while that to Amikacin was the lowest, at 2.0%. The drug-resistance rates of P. aeruginosa to 17 antibiotics showed a gradual upward trend in the three years. Conclusion P. aeruginosa are highly resistant to Ceftriaxone, Cefotaxime and Imipenem while sensitive to Amikacin. The drug-resistance of P. aeruginosa shows a gradual upward trend. It is necessary to continuously monitor its drug resistance to promote rational use of antimicrobial agents and delay the emergence of drug resistant pathogens.