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Production of teicoplanin by a mutant of Actinoplanes teicomyceticus |
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| Authors: | Lee Jae-Chan Park Hae-Ryong Park Dong-Jin Son Kwang Hee Yoon Ki-Hong Kim Young-Bae Kim Chang-Jin |
| Institution: | (1) Korea Research Institute of Bioscience & Biotechnology, P.O. Box 115, Yusong, Daejon, 305-600, Korea;(2) School of Food Science & Biotechnology, Woosong University, Daejon, Korea;(3) Graduate School of Biotechnology, Korea University, Seoul, Korea |
| Abstract: | Teicoplanin, a glucopeptide antibiotic, was produced by a mutant of Actinoplanes teicomyceticus at 300 mg l–1 using mannose and yeast extract as carbon and nitrogen sources in flask culture and at 500 mg l–1 in 5-l jar fermenter. Teicoplanin production was 25-fold higher than in the parent strain. |
| Keywords: | Actinoplanes teicomyceticus Diaion HP-20 fermentation mutation teicoplanin |
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