S/D处理人纤维蛋白原的病毒灭活验证 |
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引用本文: | 李征 朱关福. S/D处理人纤维蛋白原的病毒灭活验证[J]. 微生物学免疫学进展, 1998, 26(1): 46-50 |
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作者姓名: | 李征 朱关福 |
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作者单位: | 卫生部成都生物制品研究所,中国人民解放军艾滋病检测确认实验室,中国药品生物制品检定所 |
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摘 要: | 在人纤维蛋白原制备工艺中增加S/D处理灭活病毒步骤,TNBP和Tween80终浓度分别为0.3%和1%,在25℃处理6小时能有效灭活指示病毒VSV(〉3.75Log)、Sindbis(〉4.46Log)、HIV(〉3.67Log),盲传三代未检出病毒
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关 键 词: | 人纤维蛋白原 S/D处理 病毒灭活验证 |
Validation of Virus Inactivation in Human Fibrinogen with S/D Treatment |
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Abstract: | Virus inactivation with S/D treatment was incorporated into the preparation scheme of human fibrinogen. The final concentration of TNBP and Tween80 in the solution was 0.3% and 1% respectively. The 6 hour treatment at 25℃ could sterilize the marker viruses effectively e.g VSV (>3.75Log),Sindbis(>4.46Log),HIV(>3.67Log). The viruses were not detected in the three blind passage. |
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Keywords: | Human fibrinogen S/D treatment Validation of virus inactivation |
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