Proviral progeny of heterodimeric virions reveal a high crossover rate for human immunodeficiency virus type 2 |
| |
Authors: | Mukherjee Sayandip Lee Hui-Ling Rose Ron Yacov Dougherty Joseph P |
| |
Institution: | Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA. |
| |
Abstract: | Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS in humans, exhibits a very high rate of recombination. Bearing in mind the significant epidemiological and clinical contrast between HIV-2 and HIV-1 as well as the critical role that recombination plays in viral evolution, we examined the nature of HIV-2 recombination. Towards this end, a strategy was devised to measure the rate of crossover of HIV-2 by evaluating recombinant progeny produced exclusively by heterodimeric virions. The results showed that HIV-2 exhibits a crossover rate similar to that of HIV-1 and murine leukemia virus, indicating that the extremely high rate of crossover is a common retroviral feature. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|