An opioid basis for early-phase isoflurane-induced hypotension in rats |
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Authors: | Ellenberger Elizabeth A Lucas Heather L Russo John M Mueller Janet L Barrington Peggy L Tseng Leon F Quock Raymond M |
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Affiliation: | Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USA. |
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Abstract: | This study was conducted to more clearly delineate the possible role of endogenous opioid receptors and opioid peptides in general anesthesia-associated hypotension in rats. Exposure to 2% isoflurane in oxygen produced a triphasic change in mean arterial pressure (MAP), including an early phase in which MAP fell by -28.4 +/- 2.2%. The magnitude of this early-phase hypotension was attenuated in rats pretreated with intravenous (i.v.) mu-subtype-selective doses of either naloxone or methylnaloxone but not central doses of the selective mu-opioid antagonist beta-funaltrexamine. This early hypotensive phase was also reduced following i.v. pretreatment with antiserum against methionine-enkephalin but not beta-endorphin. These findings suggest that early-phase isoflurane-induced hypotension may be due to activation of peripheral mu-opioid receptors by an endogenous opioid peptide, possibly related to methionine-enkephalin. |
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