Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp |
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Authors: | Volleková A Kostálová D Sochorová R |
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Institution: | (1) Mycological Laboratory, Department of Dermatovenerology, Slovak Postgraduate Academy of Medicine, Bratislava;(2) Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Bratislava;(3) Slovakofarma Co., Hlohovec, Slovakia |
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Abstract: | Bioassay directed fractionation of crude extract fromMahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids,
where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal activity of the crude
extract, two protoberberine alkaloids and BBI fromM. aquifolium stem bark were evaluated against six strains ofMalassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual
strains were in the range ≤50–≥1000 mg/L. |
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