The action of pertussis vaccines and GMDP on the change in the enzymatic activity of macrophages from peritoneal exudate |
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Authors: | Ermolova E V Britsina M V Ozeretskovskaia M N Shepeleva I B Zakharova N S |
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Affiliation: | Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia. |
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Abstract: | The influence of whole-cell and acellular pertussis vaccines, introduced both alone and in combination with N-acetylglucosaminylmuramyl-2-alanine-D-isoglutamine (GMDP) on the activity of two enzymes of peritoneal exudate macrophages (5'-nucleotidase and Na+K(+)-adenosine triphosphatase) was studied. The study revealed that both pertussis vaccines exhibited immunomodulating properties, these properties being most pronounced in whole-cell pertussis vaccine. The use of GMDP in combination with pertussis vaccines led to changes in the enzymatic activity of peritoneal exudate macrophages, which was indicative of a decrease in the immunomodulating action of pertussis preparations. |
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