Endosomes,receptor tyrosine kinase internalization and signal transduction |
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Authors: | John J. M. Bergeron G. M. Di Guglielmo Patricia C. Baass François Authier Barry I. Posner |
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Affiliation: | (1) Departments of Anatomy and Cell Biology, McGill University, H3A 2B2 Montreal, P.Q., Canada;(2) Department of Biochemistry, McGill University, H3A 2B2 Montreal, P.Q., Canada;(3) Department of Medicine, McGill University, H3A 2B2 Montreal, P.Q., Canada;(4) INSERM U30, Hôpital des Enfants Malades, Paris, France |
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Abstract: | Upon the binding of insulin or epidermal growth factor to their cognate receptors on the liver parenchymal plasmalemma, signal transduction and receptor internalization are near co-incident. Indeed, the rapidity and extent; of ligand mediated receptor internalization into endosomes in liver as well as other organs predicts that signal transduction is regulated at this intracellular locus. Although internalization has been thought as a mechanism to attenuate ligand mediated signal transduction responses, detailed studies of internalized receptors in isolated liver endosomes suggest an alternative scenario whereby selective signal transduction pathways can be accessed at this locus. |
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Keywords: | Endosome insulin internalization receptor signal transduction tyrosine kinase |
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